There isn’t one. However if you don’t submit MSBs for your sources by the time they are observable you could be throwing away opportunities of having your sources observed. Nevertheless, note that there is no requirement that you submit your entire project at once. Therefore you can submit some MSBs, wait for them to get done so you can analyze the results and then submit other MSBs to follow up on those results. Your MSBs will keep on being scheduled until you have exceeded the total time allocated to your project.